The major difference is molecular structure: orforglipron is a non-peptide small molecule that survives digestion, while semaglutide is peptide-based and requires injection
107 , e825e835 (2022)
Before you do anything else, set yourself up in a clean, well-lit space
It's important to understand that stopping semaglutide does not cause immediate weight gain, but it removes a significant tool that was helping to maintain weight loss
If you are self-administering your medication at home, we schedule follow-up appointments every 6 weeks either by phone or in personto monitor your progress, address any concerns, and ensure your treatment is safe and effective
However, the absence of hepatic decompensation or overt hepatotoxicity in the ESSENCE trial is reassuring and supports the use of semaglutide in patients with F2-F3 fibrosis, with appropriate monitoring